The first grand slam tennis tournament of the year is set to begin on Sunday at Melbourne Park, with the 2025 Australian Open bringing plenty of intriguing storylines. Defending champion Jannik Sinner will try to put doping allegations in the rearview mirror and defend his title, but he will have to get past players like Carlos Alcaraz and Novak Djokovic. Alcaraz won a pair of grand slams last season, while Djokovic is a 10-time Australian Open champion. Sinner also won the US Open in the final slam of the 2024 season.  

Sinner is the +150 favorite (risk $100 to win $150) in the 2025 Australian Open odds, followed by Alcaraz (+350) and Djokovic (+450). Alexander Zverev (12-1), Daniil Medvedev (15-1) and Taylor Fritz (30-1) are among the other Australian Open contenders, but should you back any of those longshots with your 2025 Australian Open bets? Before making any 2025 Australian Open picks for the men’s singles tournament, you need to see who proven SportsLine tennis handicapper Jose Onorato is backing.

Onorato grew up playing competitive tennis in Caracas, Venezuela. After coming to the U.S., he trained with famed coach Nick Bollettieri at IMG Academy in Florida and faced players like Robert Farah, now one of the world’s top-ranked doubles players.

Onorato, who holds dual degrees in finance and economics from the University of Miami, does extensive research before placing any tennis betting picks. He studies current form, players’ tendencies on a particular surface, weather conditions and many other relevant factors. That systematic approach has helped Onorato go 168-106-8 (+107.12 units) at sportsbooks and on betting apps since 2022. In the 2024 US Open, he included Sinner (+320) in his best bets.

Now, Onorato has scrutinized the latest Australian Open 2025 odds and released his coveted best bets to win it all. He’s sharing all of his picks and analysis at SportsLine.

Top 2025 Australian Open men’s predictions

Onorato is fading Djokovic, even though he is one of the top favorites and is a 10-time champion. Djokovic failed to win a grand slam during the 2024 season, highlighting the growing gap between himself and the younger generation. He suffered a shocking loss to Alexei Popyrin in the third round of the US Open, and he is coming off a loss to Reilly Opelka in Brisbane last week. 

Djokovic continues to fall down the ATP rankings and is not getting any younger, while the other top players in the draw have been improving. He is also coming off an injury that caused him to miss the ATP Finals, so there is doubt surrounding his ability to weather a two-week storm and win another slam. It is never easy fading one of the sport’s greatest players, but his reputation has led to an inflated price this year. See who else to back and fade here.

How to make 2025 Australian Open men’s picks 

Onorato has a full preview with multiple best bets, including a play on a big longshot going off higher than 25-1. You can only see his Australian Open 2025 picks and analysis at SportsLine.

Who wins the Australian Open 2025, and which enormous longshots could take the crown? Visit SportsLine now to see Onorato’s bets for the Australian Open 2025, all from the renowned tennis expert with several high-profile future wins, and find out.

2025 Men’s Australian Open odds, top contenders

See full Australian Open 2025 men’s picks, predictions and best bets here.

Jannik Sinner +150
Carlos Alcaraz +350
Novak Djokovic +450
Alexander Zverev +1200
Daniil Medvedev +1500
Taylor Fritz +3000
Stefanos Tsitsipas +4000
Jack Draper +4000
Holger Rune +4000
Alex De Minaur +5000
Andrey Rublev +6500
Giovanni Mpetshi Perricard +6500
Arthur Fils +6500
Nick Kyrgios +6500
Casper Ruud +8000
Ben Shelton +8000
Reilly Opelka +8000
Sebastian Korda +8000
Matteo Berrettini +8000
Hubert Hurkacz +8000
Grigor Dimitrov +8000
Frances Tiafoe +8000
Tommy Paul +10000