For the record, Medvedev is 6-5 against world No.1s. After benefitting from 10th seed Grigor Dimitrov’s retirement due to a knee issue at 5-3 in the opening set in the fourth round, he would love nothing more than to add Sinner to his list.

Both men reached the semifinals at the All England Club last year before lopsided defeats – Medvedev to eventual champion Alcaraz and Sinner to defending champion Djokovic.

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The 28-year-old Medvedev has not had it all his own way this fortnight, conceding sets to Alexandre Muller and Jan-Lennard Struff back-to-back.

After a tricky four-set opener against Yannik Hanfmann and a nailbiting three-hour, 42-minute scrap with countryman Matteo Berrettini, Sinner has cruised. 

Fourteenth seed Ben Shelton was his latest victim and could not muster a set.

Following his momentous comeback from two sets down to deny Medvedev at Melbourne Park in January, Sinner was not reading too heavily into that result, their most recent at a major.

“I still think that every match has its own story, especially I felt like in Australia we had two different matches in one match,” Sinner said. “It’s going to be tough for both of us. I practised with him earlier in the week. He was playing really good.

“I think the key is a little bit different because the surface is different. We have to see. I think for both of us it’s going to be very important how we serve. 

“On grass, it’s the most important shot. Then we see. It’s going to be for sure some long rallies, physical match. This I know already. I hope to be ready.”

The winner will face either reigning champion Alcaraz or 12th seed Tommy Paul.