Thanasi Kokkinakis, Jordan Thompson and Tristan Schoolkate have continued Australia’s magnificent start to the US Open with rousing first-round victories in New York.

Fan favourite Kokkinakis received a standing ovation on The Grandstand after upsetting dual grand slam runner-up Stefanos Tsitsipas 7-6 (7-5), 4-6, 6-3, 7-5 to complete a stunning Australian treble early on day three.

Incredibly, Kokkinakis’s fighting four-set triumph over the 11th seed was only his second victory at the Open in nine injury-plagued years.

The 28-year-old’s reward is a golden opportunity to finally make a grand slam run in a wide open pocket of the draw.

Kokkinakis next faces Nuno Borges or Federico Coria, with neither seeded, with Schoolkate a potential round-three opponent following the West Australian’s own watershed win over Taro Daniel.

Schoolkate vindicated his wildcard entry with a steely 4-6, 4-6, 6-4, 7-6 (8-6), 6-4 comeback victory on his long-awaited grand slam main draw debut.

The 23-year-old world No.193 earned a second-round shot at Czeck Jakub Mensik, not to mention a life-changing career pay day of at least $US140,000 ($207,000).

Thompson earlier shook off the disappointment of missing a seeding by one rankings spot to blow away Constant Lestienne 6-1, 6-3, 6-2 in less than two hours.

The world No.32 did his best to escape the searing heat by breaking the Frenchman six times without dropping his own serve even once.

Thompson will play world No.7 Hubert Hurkacz for a place in the last 32.

Australia now has seven players through to the second round, with Kokkinakis, Schoolkate and Thompson joining day-one winners Alexei Popyrin, Rinky Hijikata, Ajla Tomljanovic and 18-year-old qualifier Maya Joint.

But women’s wildcard Taylah Preston’s international grand slam debut lasted just 61 minutes in a 6-2, 6-0 first-round loss to Russian seed Anastasia Pavlyuchenkova.

And Daria Saville’s comeback from a foot injury ended in frustration and despair, the Australian No.1 losing 6-3, 4-6, 7-6 (10-6) to Japanese qualifier Ena Shibahara in a three-hour, 16-minute cliffhanger.

A whopping 13 Australians were scheduled to play on Wednesday morning (AEST), including men’s 10th seed Alex de Minaur in his eagerly-awaited return from a hip injury.

US Open day two Australia results and schedule

Thanasi Kokkinakis def Stefanos Tsitsipas 7-6 (7-5), 4-6, 6-3, 7-5

Tristan Schoolkate def Taro Daniel 4-6, 4-6, 6-4, 7-6 (8-6), 6-4

Jordan Thompson def Constant Lestienne 6-1, 6-3, 6-2

Ena Shibahara def Daria Saville 6-3, 4-6, 7-6 (10-6)

Anastasia Pavlyuchenkova def Taylah Preston 6-2, 6-0

Elena Rybakina def Destanee Aiava 6-1, 7-6 (7-1)

Still to come or in action:

Alex de Minaur v Marcos Giron

Max Purcell v Aleksandar Vukic

James Duckworth v Flavio Cobolli

Chris O’Connell v Nicolas Jarry

Li Tu v Carlos Alcaraz

Arina Rodionova v Wang Xinyu

AAP